4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

Product Name: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
CAS No.: 188591-46-0
Chemical Name: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
Synonyms: CS-710;GSK 3787;GSK3787, >=98%;GSK3787/GSK-3787;GSK3787;GSK 3787;GSK-3787;PPARβ/δ Antagonist, GSK3787;PPARβ/δ Antagonist, GSK3787 - CAS 188591-46-0 - Calbiochem;4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide;4-chloro-N-(2-(5-(trifluoromethyl)pyridin-2-ylsulfonyl)ethyl)benzamide;4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
CBNumber: CB02518837
Molecular Formula: C15H12ClF3N2O3S
Formula Weight: 392.78
MOL File: 188591-46-0.mol

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4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Property

Boiling point:: 585.1±50.0 °C(Predicted)
Density: 1.448±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO: ≥10mg/mL
form: White solid
pka: 12.92±0.46(Predicted)
color: white to off-white
Stability:: Stable for 1 year for up to year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 188591-46-0

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G7423
Product name: GSK3787
Purity: ≥98% (HPLC), white to off-white, powder
Packaging: 5mg
Price: $168
Updated: 2024/03/01

Sigma-Aldrich

Product number: 516567
Product name: PPARβ/δ Antagonist, GSK3787
Packaging: 10mg
Price: $238
Updated: 2024/03/01

Cayman Chemical

Product number: 15219
Product name: GSK3787
Purity: ≥95%
Packaging: 5mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 15219
Product name: GSK3787
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Sigma-Aldrich

Product number: G7423
Product name: GSK3787
Purity: ≥98% (HPLC), white to off-white, powder
Packaging: 25mg
Price: $662
Updated: 2023/01/07

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4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Chemical Properties,Usage,Production

Description

GSK-3787 (188591-46-0) is a selective and irreversible antagonist of the peroxisome proliferator-activated receptor δ (PPARδ) – plC50 = 6.6. It covalently binds to Cys 249 in the PPARd binding site.

Uses

GSK3787 has been used to inhibit the role of peroxisome proliferator-activated receptor-delta (PPARδ), during the pre-implantation period of bovine embryonic development. It has also been used as a PPARδ-specific inhibitor in in vitro maturation (IVM) media to inhibit PPARδ.

Uses

PPARβ/δ is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible antagonist of PPARβ/δ (pIC50 = 6.6) with no measurable affinity for PPARα or PPARγ (pIC50 >5). At 1μM, it inhibits the expression of PPARβ/δ-regulated target genes, pyruvate dehydrogenase kinase 4 and carnitine palmitoyl transferase 1a, which are important for energy homeostasis in human skeletal muscle cells. GSK3787 (at 1 μM) also antagonizes agonist-induced expression of angiopoietin-like protein 4 in mouse fibroblasts, mouse keratinocytes, and human MCF-7, Huh7, and HepG2 cancer cell lines.[Cayman Chemical]

Biochem/physiol Actions

GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.

storage

Store at +4°C

References

Shearer et al., (2010)? Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist;? J. Med. Chem.?53? 1857 Palkar?et al?(2010) Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-β/δ antagonist GSK3787; ?Mol.Pharmacol.?78? 419

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide Suppliers

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View Lastest Price from 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 188591-46-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide 188591-46-0
Price: US $9.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-12-21

188591-46-0, 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamideRelated Search:

KL001 Retinoic acid RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK583 GSK369796 GSK461364 GSK547 GSK-467 GSK481 GSK-3326595 KI16425 WY-14643 T0070907 GW0742 GW9662 Veliparib

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

GSK 3787

GSK3787/GSK-3787

Benzamide, 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-benzamide GSK 3787

4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

4-chloro-N-(2-(5-(trifluoromethyl)pyridin-2-ylsulfonyl)ethyl)benzamide

GSK3787;GSK 3787;GSK-3787

PPARβ/δ Antagonist, GSK3787

GSK3787, >=98%

CS-710

PPARβ/δ Antagonist, GSK3787 - CAS 188591-46-0 - Calbiochem

4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide USP/EP/BP

GSK3787,airreversibleperoxisomeproliferator-activatedreceptorδ(PPARδ)antagonist

188591-46-0

88591-46-0

Inhibitor

Inhibitors